My lab utilizes a combined approach of molecular genetics, biochemistry, cell and developmental biology to understand the gene-environment interactions underlying neurodegenerative diseases. We employ a diverse range of model systems including patient-derived induced pluripotent stem cells (iPSCs), neuronal culture and mouse models of Huntington's disease, Down syndrome/Alzheimer's disease and other diseases. We aim to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology, by characterizing the molecular function of disease genes and their interaction with environmental agents under both normal and pathological conditions. We are primarily studying interactions between metal and other toxicant exposures and neurodegenerative disease states.
- Aaron Bowman
Associate Professor, Pediatrics, Neurology and Biochemistry
D-4108
D-4108 MCN
Nashville, TN 37232
USA
No contact person provided
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term Keyword
Base Sequence Cell Line, Transformed developmental biology Dopamine Dopaminergic Neurons Dyneins Environmental Exposure genetics Glutamic Acid human induced pluripotent stem cells Insect Proteins Leg manganese membrane biochemistry Membrane Potential, Mitochondrial metal neurotoxicity Microscopy, Immunoelectron mouse mouse models of disease neurodegeneration neurodevelopment Neurodevelopmental disorders neuroscience Photoreceptor Cells Repressor Proteins Retinal Rod Photoreceptor Cells Risk Factors Sequence Homology, Amino Acid stem cells Testis Time Factors Toxicology toxicology Wings, Animal