The Center for Innovative Technology (CIT) is a state-of-the-art small molecule omics shared resource center and collaborative analytical facility specializing in a range of mass spectrometry and confocal screening techniques. The CIT can measure the complex array of small molecule metabolites present within a fluid, cell, or tissue and can identify reproducible steady state and/or temporal changes associated with disease state or drug administration for context dependent analysis.
Afterward, metabolite identifications are assigned based on high mass accuracy measurements, isotope distributions, tandem MS fragmentation patterns, and comparisons with spectral libraries and standards. Consequently, the results can reveal unique biochemical fingerprints of cellular processes specific to each sample. This can be exploited as a discovery-based approach for generating novel hypotheses or used for a better understanding of physiological processes mediated by genetic or environmental perturbations. If needed, new workflows can be established for method development, targeted biomolecule measurement acquisition, and/or metabolite validation.
We support investigators in numerous phases of the analytical pipeline and provide a number of routine and/or advanced services depending on the goals of your individual research projects.
As a full-service shared resource, we provide the following services:
For more detailed information and resources, please visit our website: https://www.vanderbilt.edu/cit/home/
To start a new project with the CIT, please submit a request in iLab: https://vanderbilt.corefacilities.org/sc/4369/vanderbilt-center-for-innovative-technology-cit-core?tab=about
To subscribe to bi-monthly CIT updates, please visit: https://www.vanderbilt.edu/cit/molecular-omics-updates/
“This work was supported in part using the resources of the Center for Innovative Technology at Vanderbilt University.”
Nashville, TN 37235
MeSH terms are retrieved from PubMed records. Learn more.
Key: MeSH Term KeywordAlgorithms Animals Biochemical biological networks Biomarker Discovery Biomolecular Brain Chromatography, Liquid Cisplatin Cocaine-Related Disorders Databases, Genetic Discovery Science Environmental Exposure Gases Infant, Premature Interleukin-6 Laboratories Lipidomics Lipids Mass Spectrometry metabolism Metabolism metabolomic analysis Metabolomics Mice, Inbred C57BL Microbiome Molecular Conformation Molecular Omics Multivariate Analysis Network Analysis Nucleotides Pathway Analysis Precision Medicine Pregnancy Secretome Small Molecule Libraries Temperature Untargeted Mass Spectrometry Workflow Zonula Occludens-1 Protein