The Vanderbilt Genome Editing Resource (VGER) assists investigators in generating, maintaining, and storing germline-altered mice. The resource has been in existence for over 27 years and has generated over 2,700 transgenic founder mice from over 700 different DNA constructs and 5,000 chimeric mice from over 800 different mouse ES cell clones to produce over 160 different gene-targeted mice. Since 2013, VGER has used CRISPR/Cas9 to produce over 140 precise gene mutations in mice for more than 55 investigators.
We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.
We provide the following services on a fee-for-service basis:
We no longer provide mouse ES cell-based services on a routine, fee-for-service basis (please see notification letter).
As always, we are pleased to discuss collaborative projects that involve the development of new strategies and techniques.Contact Us
Matthew Wilson and colleagues generated an important new mouse model for cystinuria Type A in a coisogenic albino background. Cystinuria Type A is a relatively common genetic kidney disease caused by mutations in the cysteine transporter rBAT, or Slc3a1, that results in cystine crystals in the urine and bladder stones. These mice are useful for in vivo imaging and for developing new treatments for cystinuria.CRISPR/Cas9 engineering of albino cystinuria Type A mice. Beckermann TM, Welch RC, Williams FM, Mortlock DP, Sha F, Ikizler TA, Woodard LE, Wilson MH. Genesis. 2020 58 (5): e23357