The Vanderbilt Genome Editing Resource (VGER) assists investigators in generating, maintaining, and storing germline-altered mice. The resource has been in existence for over 27 years and has generated over 2,700 transgenic founder mice from over 700 different DNA constructs and 5,000 chimeric mice from over 800 different mouse ES cell clones to produce over 160 different gene-targeted mice. Since 2013, VGER has used CRISPR/Cas9 to produce over 140 precise gene mutations in mice for more than 55 investigators.
We have many years of experience in generating novel transgenic mouse models and are happy to discuss your project with you.
We provide the following services on a fee-for-service basis:
As always, we are pleased to discuss collaborative projects that involve the development of new strategies and techniques.Contact Us
Nicole Fisher, Colleen Niswender and colleagues produced a genome edited mouse through VGER to model a metabotrophic glutamate receptor 7 mutation (mGlu7-I154T) reported in two sisters who present with severe developmental delay and epilepsy. The mouse model with the same amino acid change exhibits reduced mGlu7 protein levels and a range of neurological phenotypes that supports GRM7 as a causative gene in neurodevelopmental disorders.A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. Fisher NM, AlHashim A, Buch AB, Badivuku H, Samman MM, Weiss KM, Cestero GI, Does MD, Rook JM, Lindsley CW, Conn PJ, Gogliotti RG, Niswender CM. A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. JCI Insight. 2021 Feb 22;6(4):e143324. doi: 10.1172/jci.insight.143324.