Compound Screening

Compund Screening

Keywords: compound screening Compound management

Category: Collection
Record History: Added on December 13, 2013 at 10:03 AM by Gribben, Erin
Modified on January 21, 2014 at 1:57 PM by Gribben, Erin
Shared with (contributions): Public: Shared Collection

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TARGET IDENTIFICATION AND VALIDATION

ASSAY DEVELOPMENT

HIGH-THROUGHPUT SCREENING

LEAD IDENTIFICATION

PRECLINICAL DEVELOPMENT
• DMPK
• ADMET

CLINICAL DEVELOPMENT

Assay Design
How do we measure our target?
Weeks – months

Screening
Can we do HT screening?
Weeks – months

Potency and efficacy
Does it work how we want it to?
Days – weeks

Validation
Does it work?
Weeks – months

Confirmation
Can we repeat results?
Days – weeks

Selectivity
How specific is it for our target?
Days – weeks

Pilot Library Screen
Can we detect "hits"?
Days – weeks

CHEMISTRY OPTIMIZATION

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