Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell; BIG

Record History
Added on October 14, 2013 at 9:07 AM by Brown, Deborah
Modified on October 17, 2013 at 2:22 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group Master

Meeting Details

Start Date / Time October 23, 2013 at 9:00 AM
End Date / Time October 23, 2013 at 10:00 AM
Duration 1 hour(s)
Location 512 Light Hall
Presenter Name Harini Chakravarthy, PhD
Presentation Title Generation of pancreatic insulin producing β-cells from islet α-cells in vivo
Status This meeting has already occurred

Meeting Agenda/Notes

Dr. Chakravarthy is a postdoctoral fellow in Seung Kim's lab at Stanford.

The overall goal of our work is to elucidate the mechanisms responsible for maintaining cell identity. Recent studies have shown that under conditions of extreme pancreatic beta cell loss in mice, alpha cells within the pancreas lose their identity and take on beta cell characteristics such as the production of insulin. Our work investigates the function of two genes: DNA methyltransferase 1 (Dnmt1) and Arx in maintaining alpha cell identity in adult mice. Our results show that simultaneous alpha-cell specific deletion of Dnmt1 and Arx causes a large proportion of alpha cells to lose alpha cell identity and rapidly convert into insulin producing cells.