Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 12:05 PM by Brown, Deborah
Modified on October 31, 2014 at 12:04 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time November 12, 2014 at 9:00 AM
End Date / Time November 12, 2014 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Holly Cyphert (Stein)
Presentation Title “The Characterization of MafB in Adult β-cells"
Status This meeting has already occurred

Meeting Agenda/Notes

MafA and MafB have been identified as pancreatic islet-enriched transcription factors that regulate the development and function of mouse β-cells. MafB is first involved in promoting embryonic endocrine cells into adult rodent β-cells while MafA regulates insulin expression and secretion in the adult rodent β-cell. Notably, human adult β-cells express both MafA and MafB while mouse adult β-cells only express MafA. Information is limited as to why these factors are expressed differently between species. To understand the role of MafB (and the MafA/MafB heterodimer in adult β-cells), we have developed a mouse model that misexpresses MafB in the adult β-cell, along with MafA (termed MafBtg). This talk will highlight the characteristics of MafBtg model and the context and species-specific roles of MafA and MafB.