|Start Date / Time||November 12, 2014 at 9:00 AM|
|End Date / Time||November 12, 2014 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Holly Cyphert (Stein)|
|Presentation Title||“The Characterization of MafB in Adult β-cells"|
|Status||This meeting has already occurred|
MafA and MafB have been identified as pancreatic islet-enriched transcription factors that regulate the development and function of mouse β-cells. MafB is first involved in promoting embryonic endocrine cells into adult rodent β-cells while MafA regulates insulin expression and secretion in the adult rodent β-cell. Notably, human adult β-cells express both MafA and MafB while mouse adult β-cells only express MafA. Information is limited as to why these factors are expressed differently between species. To understand the role of MafB (and the MafA/MafB heterodimer in adult β-cells), we have developed a mouse model that misexpresses MafB in the adult β-cell, along with MafA (termed MafBtg). This talk will highlight the characteristics of MafBtg model and the context and species-specific roles of MafA and MafB.