Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:57 AM by Brown, Deborah
Modified on September 16, 2014 at 4:53 PM by Magnuson, Mark
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time September 17, 2014 at 9:00 AM
End Date / Time September 17, 2014 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Yu-Ping Yang (Wright lab)
Presentation Title The 5’ Mammal-Specific Area II in Pdx1: A Multi-Transcription Factor Recruitment Region Essential for Endocrine Specification and beta Cell Maturation”
Status This meeting has already occurred

Meeting Agenda/Notes

Pdx1 is essential for pancreatic progenitor formation/differentiation.  However, it remains unknown how the very dynamic patterns of Pdx1 expression, regulated via specific cis-regulatory modules, are linked to is function.  The compact, highly conserved 5’ Area II region contains binding sites for multiple endocrine/beta cell transcription factors and has beta-cell-specific promoter activity.  We hypothesized that Area II is the primary control element for Pdx1 in differentiating and mature beta cells.  We tested this idea genetically by generating mouse mutants carrying Area II deletion.  I will discuss how removal of Area II results in large transcriptional and epigenetic influences on the endocrine program, with strong effects in endocrine specification and beta cell maturation.