Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:56 AM by Brown, Deborah
Modified on August 28, 2014 at 12:07 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time September 3, 2014 at 9:00 AM
End Date / Time September 3, 2014 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Eric Bankaitis (Wright)
Presentation Title Morphogenesis and Differentiation in the Pancreatic Endocrine Progenitor Niche
Status This meeting has already occurred

Meeting Agenda/Notes

Endocrine cells arise from a branched, remodeling epithelium throughout mouse pancreas development.  During the “secondary transition” period of cellular differentiation, a specialized epithelial 'trunk' domain allocates endocrine (Ngn3+) or duct cell lineages from a common, bi-potent Sox9+ progenitor pool.  While transcription factors that direct progenitors toward an endocrine fate are well studied, it remains unclear whether and how “niche” environments are organized and deployed within the trunk to regulate endocrine cell birth.  I will present evidence that endocrine lineage allocation is sub-compartmentalized within the trunk, and discuss my ongoing effort to understand how the unique properties of this environment integrate morphogenesis and cellular differentiation.