|Start Date / Time||September 3, 2014 at 9:00 AM|
|End Date / Time||September 3, 2014 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Eric Bankaitis (Wright)|
|Presentation Title||Morphogenesis and Differentiation in the Pancreatic Endocrine Progenitor Niche|
|Status||This meeting has already occurred|
Endocrine cells arise from a branched, remodeling epithelium throughout mouse pancreas development. During the “secondary transition” period of cellular differentiation, a specialized epithelial 'trunk' domain allocates endocrine (Ngn3+) or duct cell lineages from a common, bi-potent Sox9+ progenitor pool. While transcription factors that direct progenitors toward an endocrine fate are well studied, it remains unclear whether and how “niche” environments are organized and deployed within the trunk to regulate endocrine cell birth. I will present evidence that endocrine lineage allocation is sub-compartmentalized within the trunk, and discuss my ongoing effort to understand how the unique properties of this environment integrate morphogenesis and cellular differentiation.