|Start Date / Time||August 20, 2014 at 9:00 AM|
|End Date / Time||August 20, 2014 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Leslie Ann Roteta (Vickers)|
|Presentation Title||HDL-microRNA Intercellular Communication in Type 2 Diabetes|
|Status||This meeting has already occurred|
microRNAs (miRNAs) are powerful regulators of glucose metabolism and contribute to the pathogenesis of type 2 diabetes (T2D). Recently, we reported that high-density lipoproteins (HDL) transport and deliver functional miRNAs to recipient cells. Islet miRNAs, namely miR-375, are exported from beta cells in vitro to HDL and this export is altered by glucose concentrations. Additionally, smRNA sequencing of HDL from human diabetic subjects and the ZDF diabetic rat model, demonstrated altered HDL-miRNA profiles compared to healthy controls. Furthermore, the HDL-miRNA profile is corrected back to a healthy profile upon restoring beta cell function with Colesevelam treatment. Collectively, this data suggest that miRNAs in plasma, livers, and pancreatic islets are highly sensitive to glycemic conditions and beta cell function. This further supports the notion of HDL-miRNAs being a novel form of endocrine-like communication in T2D.