Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:55 AM by Brown, Deborah
Modified on August 15, 2014 at 12:13 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time August 20, 2014 at 9:00 AM
End Date / Time August 20, 2014 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Leslie Ann Roteta (Vickers)
Presentation Title HDL-microRNA Intercellular Communication in Type 2 Diabetes
Status This meeting has already occurred

Meeting Agenda/Notes

microRNAs (miRNAs) are powerful regulators of glucose metabolism and contribute to the pathogenesis of type 2 diabetes (T2D). Recently, we reported that high-density lipoproteins (HDL) transport and deliver functional miRNAs to recipient cells. Islet miRNAs, namely miR-375, are exported from beta cells in vitro to HDL and this export is altered by glucose concentrations. Additionally, smRNA sequencing of HDL from human diabetic subjects and the ZDF diabetic rat model, demonstrated altered HDL-miRNA profiles compared to healthy controls. Furthermore, the HDL-miRNA profile is corrected back to a healthy profile upon restoring beta cell function with Colesevelam treatment. Collectively, this data suggest that miRNAs in plasma, livers, and pancreatic islets are highly sensitive to glycemic conditions and beta cell function. This further supports the notion of HDL-miRNAs being a novel form of endocrine-like communication in T2D.