|Start Date / Time||July 16, 2014 at 9:00 AM|
|End Date / Time||July 16, 2014 at 10:00 AM|
|Location||512 Light Hall|
|Presenter Name||Elizabeth Conrad (Stein)|
|Presentation Title||efining the interrelationship between MafA and MafB in postnatal β-cell formation and function|
|Status||This meeting has already occurred|
MafA and MafB are expressed in distinct temporal windows in β-cell development. While MafA has been well studied for its role in β-cell maturation and function, the role of MafB is poorly understood as the global knockout mouse dies at birth. I have used a MafB floxed allele to analyze the individual role of this protein in postnatal β- and α-cell formation and function. In addition, I have analyzed the impact of loss of both MafA and MafB on these processes. I will also discuss differences in the expression pattern of MafA and MafB in non-human primate and human pancreas. The significance of these findings establishes a role for MafB in β-cell development and maturation in rodents and humans alike.