Start Date / Time | July 16, 2014 at 9:00 AM |
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End Date / Time | July 16, 2014 at 10:00 AM |
Duration | 1 hour(s) |
Location | 512 Light Hall |
Presenter Name | Elizabeth Conrad (Stein) |
Presentation Title | efining the interrelationship between MafA and MafB in postnatal β-cell formation and function |
Status | This meeting has already occurred |
MafA and MafB are expressed in distinct temporal windows in β-cell development. While MafA has been well studied for its role in β-cell maturation and function, the role of MafB is poorly understood as the global knockout mouse dies at birth. I have used a MafB floxed allele to analyze the individual role of this protein in postnatal β- and α-cell formation and function. In addition, I have analyzed the impact of loss of both MafA and MafB on these processes. I will also discuss differences in the expression pattern of MafA and MafB in non-human primate and human pancreas. The significance of these findings establishes a role for MafB in β-cell development and maturation in rodents and humans alike.