Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:51 AM by Brown, Deborah
Modified on July 10, 2014 at 2:44 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time July 16, 2014 at 9:00 AM
End Date / Time July 16, 2014 at 10:00 AM
Duration 1 hour(s)
Location 512 Light Hall
Presenter Name Elizabeth Conrad (Stein)
Presentation Title efining the interrelationship between MafA and MafB in postnatal β-cell formation and function
Status This meeting has already occurred

Meeting Agenda/Notes

MafA and MafB are expressed in distinct temporal windows in β-cell development. While MafA has been well studied for its role in β-cell maturation and function, the role of MafB is poorly understood as the global knockout mouse dies at birth. I have used a MafB floxed allele to analyze the individual role of this protein in postnatal β- and α-cell formation and function. In addition, I have analyzed the impact of loss of both MafA and MafB on these processes. I will also discuss differences in the expression pattern of MafA and MafB in non-human primate and human pancreas. The significance of these findings establishes a role for MafB in β-cell development and maturation in rodents and humans alike.