|Start Date / Time||June 18, 2014 at 9:00 AM|
|End Date / Time||June 18, 2014 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Ray Pasek (Gannon)|
|Presentation Title||Connective tissue growth factor promotes beta-cell proliferation|
|Status||This meeting has already occurred|
Ctgf is a secreted protein expressed in beta-cells during embryogenesis, pregnancy, and other periods of beta-cell mass expansion. Our preliminary data indicates that decreased Ctgf causes gestational diabetes in mice, at least in part due to insufficient beta-cell replication. Conversely, exogenous Ctgf increases β-cell proliferation during embryogenesis, as well as inducing proliferation of adult mouse β-cells ex vivo. For these reasons, we are exploring the potential use of Ctgf as a therapeutic to increase functional human β-cell mass.