Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:48 AM by Brown, Deborah
Modified on May 28, 2014 at 4:31 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time June 18, 2014 at 9:00 AM
End Date / Time June 18, 2014 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name Ray Pasek (Gannon)
Presentation Title Connective tissue growth factor promotes beta-cell proliferation
Status This meeting has already occurred

Meeting Agenda/Notes

Ctgf is a secreted protein expressed in beta-cells during embryogenesis, pregnancy, and other periods of beta-cell mass expansion. Our preliminary data indicates that decreased Ctgf causes gestational diabetes in mice, at least in part due to insufficient beta-cell replication. Conversely, exogenous Ctgf increases β-cell proliferation during embryogenesis, as well as inducing proliferation of adult mouse β-cells ex vivo.  For these reasons, we are exploring the potential use of Ctgf as a therapeutic to increase functional human β-cell mass.