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Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.
|Start Date / Time||May 14, 2014 at 9:00 AM|
|End Date / Time||May 14, 2014 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Ryan Ceddia (Breyer)|
|Presentation Title||The role of the prostaglandin E2 EP3 receptor in obesity, insulin resistance, and glycemic control|
|Status||This meeting has already occurred|
PGE2 is known to suppress glucose stimulated insulin secretion and this is thought to occur through the Gαi coupled EP3 receptor. Knockout of the EP3 receptor was investigated as a means of improving glucose homeostasis. However, global knockout of the EP3 receptor predisposes mice to obesity and causes lipid redistribution to ectopic tissues. This results in increased insulin resistance in EP3-/- mice that are fed a high fat diet.
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Released July 13, 2020