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Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.
|Start Date / Time||April 9, 2014 at 9:00 AM|
|End Date / Time||April 9, 2014 at 10:00 AM|
|Location||512 Light Hall|
|Presenter Name||Spencer Willet (Wright)|
|Presentation Title||Dominant Control of Endodermal Organ Allocation by the Transcription Factor Ptf1a|
|Status||This meeting has already occurred|
Using doxycycline-controlled misexpression of a presumed pancreatic commitment transcription factor, Ptf1a, we show that transient Ptf1a expression in the early embryonic mouse endoderm is sufficient to expand the pancreatic gene regulatory network within the posterior foregut. Upon later differentiation, the entire glandular stomach, anterior duodenum, and much of the extrahepatic biliary system are replaced by pancreatic cell fates.
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Released July 13, 2020