Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:20 AM by Brown, Deborah
Modified on March 21, 2014 at 12:16 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time March 26, 2014 at 9:00 AM
End Date / Time March 26, 2014 at 10:00 AM
Duration 1 hour(s)
Location 512 Light Hall
Presenter Name Kristie Aamodt (Powers)
Presentation Title Signals in the Islet Microenvironment Modulated by Vascular Endothelial Growth Factor A Promote Beta Cell Proliferation
Status This meeting has already occurred

Meeting Agenda/Notes

Summary: Overexpressing vascular endothelial growth factor A (VEGF-A) in mature beta cells leads to endothelial cell expansion and beta cell loss followed by a transient, but robust increase in beta cell proliferation. This proliferation occurs in response to signals derived from the local islet microenvironment composed of endocrine cells, endothelial cells, and macrophages recruited to islets upon VEGF-A overexpression.