Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: beta cell BIG

Record History
Added on September 11, 2013 at 11:11 AM by Brown, Deborah
Modified on January 24, 2014 at 3:24 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Seminar Master

Meeting Details

Start Date / Time January 29, 2014 at 9:00 AM
End Date / Time January 29, 2014 at 10:00 AM
Duration 1 hour(s)
Location 512 Light Hall
Presenter Name Alessandro Ustione (Piston)
Presentation Title Investigating the multiple functions of dopamine signaling in the islets
Status This meeting has already occurred

Meeting Agenda/Notes

The main focus of my current research is to identify the molecular mechanism by which dopamine regulates glucose stimulated insulin secretion from the mouse pancreatic islet.  Dopamine alters the calcium dynamics in the islet when it binds to the D3 receptor, but the link between the activated receptor and intracellular Ca2+ is yet to be determined. I am testing the hypothesis that the D3 receptor activates the GIRK channels. In addition to its effect on insulin secretion, I am also investigating the effects of dopamine on the other islet cell types, to determine if dopamine also plays a role as a paracrine signal to coordinate hormone secretion. I will present the latest results and the future directions.