Start Date / Time | December 11, 2013 at 9:00 AM |
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End Date / Time | December 11, 2013 at 9:55 AM |
Duration | 55 minutes |
Location | 512 ight Hall |
Presenter Name | Kayla Boortz (O'Brien) |
Presentation Title | Exploring the Function of G6PC2 in Pancreatic Islet Beta Cells |
Status | This meeting has already occurred |
I will be discussing my work relating to efforts
to determine the function of G6PC2 in pancreatic islet beta cells.
I will discuss prior work done in the lab that lead to the
hypothesis that G6PC2 regulates fasting blood glucose levels and my
recent discovery that glucocorticoids regulate G6PC2 promoter
activity in both humans and mice. This observation provides the
basis of my thesis work which will be focused on the hypothesis
that induction of G6PC2 by glucocorticoids is a regulatory
mechanism that is important for blunting insulin secretion under
conditions of stress. My research will involve multiple different
glucocorticoid experimental paradigms as well as a variety of
experimental approaches in order to best assess the differences in
glucose stimulated insulin secretion between G6pc2 KO and
WT mice.