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Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.


Record History
Added on October 4, 2012 at 3:03 PM by Brown, Deborah
Modified on March 21, 2013 at 10:49 AM by Brown, Deborah
Shared with (contributions)
Public: Beta Cell Interest Group (BIG) Weekly Seminar
BIG: Beta Cell Interest Group (BIG) Weekly Seminar Master

Meeting Details

Start Date / Time March 27, 2013 at 9:00 AM
End Date / Time March 27, 2013 at 10:00 AM
Duration 1 hour(s)
Location 512 Light Hall
Presenter Name Natalia Tamarina, PhD, Univ Chicago
Presentation Title Role of Heat Shock Protein 90 in insulin secretion
Status This meeting has already occurred

Meeting Agenda/Notes

In the face of high demand for insulin production, pancreatic ß-cells are prone to chronic proteotoxic stress, which is triggered by the appearance of non-native and damaged proteins and can lead to defective insulin secretion and diabetes. Heat shock protein 90 isoforms are key regulators of stress response pathways and normal cellular proteostasis. In this talk I discuss the experiments designed to investigate the molecular mechanisms by which Hsp90 chaperone machinery is involved in modulating ß-cell insulin secretion.