Amanda Ruelas (Grad student, DelGiorno Lab)
Amelia Cephas (Grad student, DelGiorno Lab)

Keywords: VCSCB SPRING seminar

Record History
Added on August 9, 2022 at 12:33 PM by Uttz, Pam
Modified on September 29, 2022 at 2:35 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time October 5, 2022 at 9:00 AM
End Date / Time October 5, 2022 at 10:00 AM
Duration 1 hour(s)
Location Zoom
Presenter Name Amanda Ruelas, Amelia Cephas (grad students)
Presentation Title See Below
Status This meeting is currently scheduled

Meeting Agenda/Notes

Students and Postdocs

Amelia Cephas

“Pancreatic Ductal-Derived Metaplasia and Neoplasia”

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths in the United States and will likely become the second by 2030. While ductal cells are known as the dominant cell of origin in humans, current mouse models show that ducts are refractory to transformation. Using a combination of genetically engineered mouse models, immunohistology and bioinformatic analyses, I will describe our current efforts to investigate the pathological and genetic changes to pancreatic ducts in response to oncogenic mutations in chronic injury, which enhances their susceptibility to transformation.

Amanda Ruelas

"Tuft Cells Inhibit Pancreatic Injury Through the
Synthesis and Secretion of IL-25"

Tuft cells are solitary chemosensory cells that are normally absent from the murine pancreas but transdifferentiate from acinar cells in response to chronic injury or oncogenic mutation. We have found that tuft cell ablation enhances pancreatitis and alters the immune infiltrate. Preliminary data show that tuft cells are the solitary source of anti-inflammatory cytokine IL-25 in pancreatitis and pancreas specific ablation of IL25 enhances pancreatic injury. We are using genetically engineered mouse models to test the hypothesis that tuft cells inhibit inflammation and preserve organ function through the synthesis and secretion of IL-25.

Attachment

Document SPRING_Meeting_10.05.22.pdf - Added on September 29, 2022 at 2:35 PM by Pam Uttz