We encourage you to work with us to perform CRISPR genome-editing in human iPSCs or to develop CRISPR inhibition models. We have acquired line AICS-0090 from the Allen Cell Collection. These human iPSCs constitutively express dCas9-KRAB, enabling gene repression upon the introduction of gRNAs. CRISPRi iPSCs can be differentiated towards a variety of cell lineages. In this manner, the function of genes, distal and proximal cis-regulatory factors, and lncRNAs can be determined in a cell-based system.


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Added on June 14, 2022 at 8:46 AM by Skelton, Jennifer
Modified on June 14, 2022 at 8:48 AM by Skelton, Jennifer
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