A C57Bl6/J strain contains a Grm7 I154T point mutation. This mutation is clinically associated with a severe neurodevelopmental disorder with profound intellectual disability and seizures. The model is intended to try to mimic these phenotypes in mice and then test if small molecules developed for Grm7 within the Vanderbilt Center for Neuroscience Drug Discovery can correct these deficits. 


Record History
Added on February 8, 2022 at 9:55 AM by Skelton, Jennifer
Modified on February 8, 2022 at 10:01 AM by Skelton, Jennifer
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VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Grm7 I154T
VCMR ID AAM
Date Cryopreserved 2020-01-07
Method of Cryopreservation Sperm
Trial IVF % Fertilization 42.42%

Genetic Alteration

Mutation #1: Nuclease-Mediated
Allele Name: glutamate receptor, metabotropic 7; endonuclease mediated mutation 1, C. Niswender
Symbol: Grm7em1
Zygosity at cryopreservation Heterozygous
PCR Genotyping Protocol Genotyping_Protocol_AAM.pdf
Citations
Publication
A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. (2021) JCI Insight 6: (Added 1/29/2021)
PMID: 33476302

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background C57BL/6J
Cryopreservation Strain Background (VCMR) C57BL/6J
Viability and Fertility Data

Heterozygotes are viable and fertile.  Homozygous males may be poor breeders.