Do you want to determine the role of a distal or proximal regulatory element? Generating a precise CRISPR-mediated intergenic deletion in mice is an excellent way to begin exploring the function of a gene regulatory region in a relevant, complex model. Intergenic DNA deletions can also be used to study the effects of human genome wide-associated single nucleotide polymorphism (GWAS) mutations in human iPSCs and in mice if the target locus is highly conserved.


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Added on December 14, 2021 at 12:53 PM by Skelton, Jennifer
Modified on December 14, 2021 at 12:53 PM by Skelton, Jennifer
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