|Start Date / Time||November 3, 2021 at 9:00 AM|
|End Date / Time||November 3, 2021 at 10:00 AM|
|Presenter Name||Ken Lau, Ph.D.|
|Presentation Title||Cellular plasticity and stability in gut health and disease|
|Status||This meeting has already occurred|
Membership Renewal talk
The Lau Lab’s research is interested in cellular plasticity of ileal and colonic epithelial cells upon differential exposure to an intact microenvironment (microbes/immune cells). Our lab uses sequencing-based -omics techniques and associated computational approaches to decipher the fate choices and functions of differentiated/differentiating/metastable cells in the gut. Here, we review our recent work on metaplastic transition of serrated polyps and its consequences on cytotoxic T cell interaction, and newer work on the consequences of manipulating Paneth cells in microbial-induced colitis. This talk will be focused on the value of experimental validation as opposed to tissue profiling and characterization. We will also emphasize our short- and medium-term future plans to further these studies.