|Start Date / Time||October 6, 2021 at 9:00 AM|
|End Date / Time||October 6, 2021 at 10:00 AM|
|Presenter Name||Rebecca Ihrie, Ph.D.|
|Presentation Title||Quantitative Dissection of Progenitor Cell Signaling in Brain Development|
|Status||This meeting has already occurred|
Membership Renewal talk
In this membership renewal talk, I will detail our collaborative work to understand the requirement for components of the mTOR signaling pathway in neural development. mTOR is a central regulator of cell size, protein production, and growth, and mutations affecting its activity have been identified in a wide range of neurodevelopmental disorders termed “mTORopathies”. Despite the clear requirement for finely tuned regulation of this pathway, relatively little is known about how specific mutations result in particular phenotypes – e.g. tumor development – while others do not. I will present a subset of our work using single-cell approaches to understand the mechanistic consequences of mTOR pathway disruption at different stages and locations in neural development.