Rebecca Ihrie, Ph.D.
Associate Professor of Cell and Developmental Biology
Associate Professor of Neurological Surgery



Keywords: vcscb SPRING seminar

Record History
Added on August 11, 2021 at 3:56 PM by Uttz, Pam
Modified on October 27, 2021 at 9:49 AM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time October 6, 2021 at 9:00 AM
End Date / Time October 6, 2021 at 10:00 AM
Duration 1 hour(s)
Location Zoom
Presenter Name Rebecca Ihrie, Ph.D.
Presentation Title Quantitative Dissection of Progenitor Cell Signaling in Brain Development
Status This meeting has already occurred

Meeting Agenda/Notes

Membership Renewal talk

In this membership renewal talk, I will detail our collaborative work to understand the requirement for components of the mTOR signaling pathway in neural development. mTOR is a central regulator of cell size, protein production, and growth, and mutations affecting its activity have been identified in a wide range of neurodevelopmental disorders termed “mTORopathies”. Despite the clear requirement for finely tuned regulation of this pathway, relatively little is known about how specific mutations result in particular phenotypes – e.g. tumor development – while others do not. I will present a subset of our work using single-cell approaches to understand the mechanistic consequences of mTOR pathway disruption at different stages and locations in neural development.


Document SPRING_Meeting_10.06.21_Ihrie.pdf - Added on October 27, 2021 at 9:49 AM by Pam Uttz