Conventional global knockout of the Grem2 exon 2 gene by homologous recombination.

Keywords: PRDC Grem2 Knockout

Record History
Added on May 25, 2021 at 1:07 PM by Skelton, Jennifer
Modified on May 25, 2021 at 1:14 PM by Skelton, Jennifer
Shared with (contributions)
VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Grem2 KO
VCMR ID UU
Date Cryopreserved 2017-05-09
Method of Cryopreservation Sperm
Trial IVF % Fertilization 81.00%

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Allele Name: gremlin 2, DAN family BMP antagonist; targeted mutation 1, Antonios Hatzopoulos
Symbol: Grem2tm1Akh
MGI: 6343527
Zygosity at cryopreservation Heterozygous
PCR Genotyping Protocol Genotyping_Protocol_UU.pdf
Citations
Publication
BMP Antagonist Gremlin 2 Limits Inflammation After Myocardial Infarction. (2016) Circ Res 119: 434-49 (Added 7/5/2016)
PMID: 27283840

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background 129
Cryopreservation Strain Background (VCMR) 129
Viability and Fertility Data

Heterozygous viable and fertile.