The first selenocysteine amino acid residue of Sepp1 has been mutated to a serine.  This results in decreased enzymatic activity of Sepp1.  In addition, multiple shortened forms of the protein are made and found in the plasma.

Record History
Added on May 20, 2021 at 11:01 AM by Skelton, Jennifer
Modified on February 8, 2022 at 9:42 AM by Skelton, Jennifer
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VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Sepp1 U40S
Date Cryopreserved 2014-08-05
Method of Cryopreservation Sperm
Trial IVF % Fertilization 28.00%

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Allele Name: selenoprotein P; targeted mutation 4.1, Raymond F Burk
Symbol: Selenoptm4.1Rfb
MGI: MGI:5616347
Zygosity at cryopreservation Homozygous
PCR Genotyping Protocol Genotyping_Protocol_SS.pdf
Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. (2014) Free Radic Biol Med 69: 67-76 (Added 3/10/2014)
PMID: 24434121

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background C57BL/6
Cryopreservation Strain Background (VCMR) C57BL/6J
Viability and Fertility Data

Homozygous and heterozygous viable and fertile.