The first selenocysteine amino acid residue of Sepp1 has been mutated to a serine.  This results in decreased enzymatic activity of Sepp1.  In addition, multiple shortened forms of the protein are made and found in the plasma.

Keywords: U40S Sepp1 Burk

Record History
Added on May 20, 2021 at 11:01 AM by Skelton, Jennifer
Modified on May 20, 2021 at 11:04 AM by Skelton, Jennifer
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VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Sepp1 U40S
VCMR ID SS
Date Cryopreserved 2014-08-05
Method of Cryopreservation Sperm
Trial IVF % Fertilization 28.00%

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Allele Name: selenoprotein P; targeted mutation 4.1, Raymond F Burk
Symbol: Selenoptm4.1Rfb
MGI: MGI:5616347
Zygosity at cryopreservation Homozygous
PCR Genotyping Protocol Genotyping_Protocol_SS.pdf
Citations
Publication
Sepp1(UF) forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1. (2014) Free Radic Biol Med 69: 67-76 (Added 3/10/2014)
PMID: 24434121

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background C57BL/6
Cryopreservation Strain Background (VCMR) C57BL/6J
Viability and Fertility Data

Homozygous and heterozygous viable and fertile.