The Sepp1 gene is flanked by loxP sites.  When mated with the desired cre-recombinase mouse, Sepp1 is deleted from cells that express the cre.

Record History
Added on May 20, 2021 at 10:46 AM by Skelton, Jennifer
Modified on February 8, 2022 at 9:41 AM by Skelton, Jennifer
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VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Sepp1 Floxed
Date Cryopreserved 2014-08-12
Method of Cryopreservation Sperm
Trial IVF % Fertilization 40.00%

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Allele Name: selenoprotein P; targeted mutation 3.1, Raymond F Burk
Symbol: Selenoptm3.1Rfb
MGI: MGI:5466366
Zygosity at cryopreservation Homozygous
PCR Genotyping Protocol Genotyping_Protocol_SV.pdf
Production of selenoprotein P (Sepp1) by hepatocytes is central to selenium homeostasis. (2012) J Biol Chem 287: 40414-24 (Added 3/7/2014)
PMID: 23038251

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background C57BL/6
Cryopreservation Strain Background (VCMR) C57BL/6J
Viability and Fertility Data

Heterozygous and homozygous viable and fertile.