Young-Jae Nam, Ph.D.
Assistant Professor of Medicine and Cell and Developmental Biology


Record History
Added on October 22, 2020 at 2:04 PM by Uttz, Pam
Modified on June 30, 2021 at 11:51 AM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time April 21, 2021 at 9:00 AM
End Date / Time April 21, 2021 at 10:00 AM
Duration 1 hour(s)
Location Zoom
Presenter Name Young-Jae Nam, Ph.D.
Presentation Title Fibroblast fate determination by remodeling fibroblast cytoskeleton during cardiac reprogramming
Status This meeting has already occurred

Meeting Agenda/Notes

A central problem of heart diseases is that cardiomyocytes are irreversibly lost and replaced by cardiac fibrosis.  Thus, the cardiac reprogramming approach is particularly attractive in that it directly targets a major source of cardiac fibrosis, cardiac fibroblasts, to induce new cardiomyocytes.  It has been shown that forced expression of core cardiogenic transcription factors (i.e. Gata4, Mef2c, and Tbx5 with or without Hand2) is able to reprogram fibroblasts into induced cardiomyocyte-like cells (iCMs) in vitro and in vivo.  This talk will focus on how cardiac reprogramming can direct a fibroblast cell fate toward a cardiac muscle fate in the context of simultaneous fibrogenic transformation processes of fibroblasts.

Attachment

Document SPRING_Meeting_04.21.2021.pdf - Added on June 30, 2021 at 11:50 AM by Pam Uttz