|Start Date / Time||February 24, 2021 at 9:00 AM|
|End Date / Time||February 24, 2021 at 10:00 AM|
|Presenter Name||Jimin Min, Ph.D.|
|Presentation Title||Plasticity of CD133+CD166+CD44- dysplastic stem cells drives transition of dysplasia to gastric cancer|
|Status||This meeting has already occurred|
Gastric cancer usually develops within a cascade of pre-cancerous metaplasia to cancerous dysplasia and adenocarcinoma and oncogenic Kras amplification and overexpression are associated with gastric carcinogenesis. The dysplastic stage is especially considered a key transition state between pre-cancer and cancer, however the cellular plasticity or tumorigenic potential of the dysplastic cell lineages remain largely unknown. Our group has recently identified dysplastic stem cell populations in active-Kras driven mouse dysplasia and this study is to investigate functional roles of the dysplastic stem cells during the cancer transition.