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B6N;Fam120btm1a(EUCOMM)Hmgu/Macara/Vu

Fam120b-/- mice were crossed with FLP mice used to remove the lacZ site was Gt(ROSA)26Sor<tm1(FLP1)Dym.  

Record History
Added on August 17, 2020 at 12:26 PM by Skelton, Jennifer
Modified on August 17, 2020 at 12:34 PM by Skelton, Jennifer
Shared with (contributions)
VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Fam120B floxed; SAN1 floxed
VCMR ID YU
Date Cryopreserved 2018-06-12
Method of Cryopreservation Sperm
Trial IVF % Fertilization 28.00%

Genetic Alterations

Mutation #1: Targeted Mutagenesis
Allele Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Susan Dymecki
Symbol: Gt(ROSA)26Sortm1(FLP1)Dym
MGI: 2429412
Zygosity at cryopreservation Homozygous
PCR Genotyping Protocol Not provided
Citations
Publication
A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links. (2018) Nat Commun 9: 2592 (Added 8/17/2020)
PMID: 29968717
Mutation #2: Targeted Mutagenesis
Allele Name: family with sequence similarity 120, member B; targeted mutation 1a, Hemholtz Zentrum Muenchen GmbH
Symbol: Fam120btm1a(EUCOMM)Hmgu
MGI: 4458741
Zygosity at cryopreservation Homozygous
PCR Genotyping Protocol SAN1KOmice1.pdf
Citations
Publication
A senataxin-associated exonuclease SAN1 is required for resistance to DNA interstrand cross-links. (2018) Nat Commun 9: 2592 (Added 8/17/2020)
PMID: 29968717

Background Strain Information

Strain Type Mixed
Chimera/Founder Genetic Background C57BL/6NHsd
Cryopreservation Strain Background (VCMR) C57BL/6NHsd
Viability and Fertility Data

Homozygous and heterozygous viable and fertile.