Julie Bejoy, Ph.D.
Postdoctoral Fellow, Woodard Lab
(trainee presentation)

 
Megan Rasmussen
 Graduate Student, Gama Lab
 (trainee presentation)


Record History
Added on July 23, 2020 at 12:08 PM by Uttz, Pam
Modified on September 18, 2020 at 3:45 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time September 23, 2020 at 9:00 AM
End Date / Time September 23, 2020 at 10:00 AM
Duration 1 hour(s)
Location Zoom
Presenter Name Julie Bejoy, Ph.D. and Megan Rasmussen
Presentation Title TBD
Status This meeting has already occurred

Meeting Agenda/Notes

Megan Rasmussen - “MCL-1 regulation of mitochondrial dynamics and homeostasis in iPSC-derived cardiomyocytes”

MCL-1 is a well-characterized inhibitor of cell death that has also been shown to be a regulator of mitochondrial dynamics in human induced pluripotent stem cells (hiPSCs). We used hiPSC-derived cardiomyocytes (hiPSC-CMs) to uncover whether MCL-1 is necessary for cardiac function and survival. BH3 mimetics targeting MCL-1 are promising anti-tumor therapeutics. We show that BH3 mimetics targeting MCL-1 cause abnormal mitochondrial network morphology and cardiac performance. Our results emphasize the need for a more complete molecular understanding of MCL-1’s mechanism of action in human cardiomyocytes, as it may reveal new approaches to prevent potential cardiac toxicities associated with chemotherapeutic inhibition of MCL-1.

Julie Bejoy, Ph.D.  - “Incorporation of Urine-Derived Stem Cells into Injured Human Kidney Organoids”

Because of their renal origin, viable cells isolated from the urinary pellet called urine-derived stem cells are a potential candidate for development of stem cell-based therapies for acute kidney injury. We induced injury in human induced pluripotent stem cell-derived kidney organoids using nephrotoxic drugs. We then evaluated the therapeutic impact and localization of labeled urine-derived stem cells when added to the injured organoids.

Attachment

Document SPRING_Meeting_09.23.20.pdf - Added on September 18, 2020 at 3:45 PM by Pam Uttz