Laura Reinholdt, PhD
Associate Professor
The Jackson Laboratory


Record History
Added on January 9, 2020 at 3:29 PM by Uttz, Pam
Modified on February 19, 2020 at 2:11 PM by Uttz, Pam
Shared with (contributions)
Public: VCSCB / PDB Seminar - CDB Seminar Series

Meeting Details

Start Date / Time March 16, 2020 at 12:10 PM
End Date / Time March 16, 2020 at 1:15 PM
Duration 1 hour(s) 5 minutes
Location 1220 MRB III
Presenter Name Laura Reinholdt, Ph.D.
Presentation Title Genetic variation influences pluripotent ground state stability in mouse embryonic stem cells through a hierarchy of molecular phenotypes
Status This meeting is currently scheduled

Meeting Agenda/Notes

  •  Mouse embryonic stem cells (mESCs) exhibit interstrain differences in derivation efficiency and differential activation of the core signaling pathways that maintain pluripotency in vitro.
  • While these phenotypic differences are well known, the underlying genetics remains a mystery. And this problem is not limited to mouse embryonic stem cells. Genetics also influences molecular phenotypes and differentiation capacity in hESCs and hiPSCs where genetic background is a dominant source of inter-line variability.
  • Taking advantage of the Diversity Outbred mouse genetic reference population, we have applied a forward genetic approach to identify the genetic variants that drive these phenotypic differences, with the goal of building predictive models of the response of mESCs to the cell culture environment.

Attachment

Document Laura_Reinholdt_flyer.pdf - Added on February 19, 2020 at 2:11 PM by Pam Uttz