|Start Date / Time||January 13, 2020 at 12:15 PM|
|End Date / Time||January 13, 2020 at 1:15 PM|
|Location||1220 MRB III|
|Presenter Name||Holger Russ, Ph.D.|
|Presentation Title||Stem Cell derived pancreatic beta cells and thymic depithelium for basic research and cell therapy|
|Status||This meeting has already occurred|
In this seminar I will discuss my labs efforts in generating functional cells of two endodermal derived tissues, the pancreas and the thymus, from human pluripotent stem cells for basic research and cell replacement therapy. We use these approaches and primary tissues in conjugation with genome engineering technologies to investigate biological question important for a better understanding of diabetes development in a strictly human context. Specifically, our recent results suggest that functional stem cell derived insulin-producing cells present as discrete, heterogenous cell populations and “most mature” beta-like cells can be identified and isolated using a surface marker. In addition, I discuss experimental evidence for the generation of patient specific thymic cells that are similar to cells present in human primary neonatal thymi.