A CD-1 strain containing a deletion from 4,493,622 - 4,493,747 in a Sox17 conserved region.  This model was created to test if the conserved DNA sequence is required for Sox17 expression specifically in the endoderm or endothelial lineages.


Record History
Added on December 20, 2019 at 3:37 PM by Skelton, Jennifer
Modified on September 6, 2022 at 8:30 AM by Skelton, Jennifer
Shared with (contributions)
VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name Sox17 CR2 in CD1
VCMR ID AAO
Date Cryopreserved 2019-12-10
Method of Cryopreservation Sperm
Trial IVF % Fertilization 78.00%

Genetic Alteration

Mutation #1: Nuclease-Mediated
Allele Name: SRY (sex determining region Y)-box17
Symbol: Sox17em2Mgn
Zygosity at cryopreservation Heterozygote
PCR Genotyping Protocol Sox17_CR2_Genotyping_Assay.docx
Citations
Publication
Differential regulation of alternate promoter regions in during endodermal and vascular endothelial development. (2022) iScience 25: 104905 (Added 9/6/2022)
PMID: 36046192

Background Strain Information

Strain Type Outbred
Chimera/Founder Genetic Background CD-1
Cryopreservation Strain Background (VCMR) CD-1
Viability and Fertility Data

Heterozygous mutant mice are viable and fertile.  Homozygous mutant animals are embryonically lethal.