Cherie Scurrah
Graduate Student, Ken Lau Lab


Record History
Added on September 26, 2019 at 12:42 PM by Uttz, Pam
Modified on October 31, 2019 at 10:06 AM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time November 6, 2019 at 9:00 AM
End Date / Time November 6, 2019 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Cherie Scurrah (Lau Lab)
Presentation Title The tumor cell-of-origin dictates tumor cell differentiation and tumor cell-microenvironment interactions
Status This meeting has already occurred

Meeting Agenda/Notes

We hypothesize that tumor heterogeneity is established and maintained by tumor initiating cells that hold a signature of the tumor cell-of-origin. Utilizing a non-stem and stem cell driven tumor model, we show that the stem cell driven tumors contain more stem-like tumor initiating cells and have a more undifferentiated phenotype compared to non-stem cell driven tumors. Furthermore, we found that tumor initiating cells within non-stem cell driven tumors have more MHC2 antigen presentation, possibly influencing its more differentiated phenotype.  These results suggest that the tumor cell of origin can influence tumor initiating cell characteristics and in turn tumor dynamics.

Attachment

Document Fall_2019_Email_Notice_Scurrah.pdf - Added on October 31, 2019 at 10:06 AM by Pam Uttz