|Start Date / Time||November 6, 2019 at 9:00 AM|
|End Date / Time||November 6, 2019 at 10:00 AM|
|Location||9455 MRB IV|
|Presenter Name||Cherie Scurrah (Lau Lab)|
|Presentation Title||The tumor cell-of-origin dictates tumor cell differentiation and tumor cell-microenvironment interactions|
|Status||This meeting has already occurred|
We hypothesize that tumor heterogeneity is established and maintained by tumor initiating cells that hold a signature of the tumor cell-of-origin. Utilizing a non-stem and stem cell driven tumor model, we show that the stem cell driven tumors contain more stem-like tumor initiating cells and have a more undifferentiated phenotype compared to non-stem cell driven tumors. Furthermore, we found that tumor initiating cells within non-stem cell driven tumors have more MHC2 antigen presentation, possibly influencing its more differentiated phenotype. These results suggest that the tumor cell of origin can influence tumor initiating cell characteristics and in turn tumor dynamics.