|Start Date / Time||October 28, 2019 at 12:15 PM|
|End Date / Time||October 28, 2019 at 1:15 PM|
|Location||1220 MRB III|
|Presenter Name||Cathy Mendelson, Ph.D.|
|Presentation Title||Genetic pathways regulating urothelial specification and bladder cancer|
|Status||This meeting has already occurred|
We have used mouse models to study the normal functions of urothelial cells as well as the molecular events that lead to bladder cancer. We find that Pparg, a nuclear receptor family member, is an important regulator that promotes differentiation of "luminal" cell types, and prevents squamous metaplasia. Pparg CNVs in humans are associated with Papillary subtype of urothelial carcinoma. We find that excess Pparg signaling in mouse models, induces urothelial carcinoma that can also promote urothelial carcinoma. Our goal is now to define the molecular and metabolic pathways controlled by Pparg, to better understand urothelial homeostasis and the events that lead to bladder cancer.