Floxed mutant mice possessing flanking loxP sites of the Ptger3 gene on Balb/C background.  The Ptger3 conditional floxed mutant mice on Balb/c background may be useful in generating conditional mutations for studying prostaglandin biology and fever response in inflammation.

Record History
Added on June 18, 2019 at 1:42 PM by Skelton, Jennifer
Modified on September 5, 2019 at 1:46 PM by Skelton, Jennifer
Shared with (contributions)
VCMR: Vanderbilt Cryopreserved Mouse Repository Master

Mouse Information

Common Name floxEP3BAL
Research Applications Not provided
MMRRC ID Not provided
Jackson Laboratories Stock No Not provided
Additional Strain Information Not provided

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Type of AlleleConditional Null
Targeted GeneName: prostaglandin E receptor 3 (subtype EP3)
Symbol: Ptger3
NCBI: 19218
Allele Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1.1, Richard M Breyer
Symbol: Ptger3tm1.1Brey
MGI: MGI:5784744
Description of Targeting Vector Not provided
Vector Genbank File Not provided
Allele Map Not Provided
PCR Genotyping Protocol Breyer_Lab_floxEP3_PCR_protocol.pdf
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. (2007) Nat Neurosci 10: 1131-3 (Added 6/18/2019)
PMID: 17676060

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background 129S6/SvEvTac
Current Genetic Background BALB/c
Number of Generations Backcrossed >5
Strain Description Not provided


Document Breyer_Lab_floxEP3_PCR_protocol.pdf - Added on June 18, 2019 at 1:42 PM by Jennifer Skelton

Document floxEP3BAL_info.docx - Added on June 18, 2019 at 1:42 PM by Jennifer Skelton