Floxed mutant mice possessing flanking loxP sites of the Ptger3 gene on Balb/C background.  The Ptger3 conditional floxed mutant mice on Balb/c background may be useful in generating conditional mutations for studying prostaglandin biology and fever response in inflammation.

Record History
Added on June 18, 2019 at 1:42 PM by Skelton, Jennifer
Modified on October 31, 2019 at 2:37 PM by Skelton, Jennifer
Shared with (contributions)
VCMR: Vanderbilt Cryopreserved Mouse Repository Master
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Mouse Information

Common Name floxEP3BAL
Date Cryopreserved 2009-09-09
Method of Cryopreservation Sperm
Trial IVF % Fertilization 5.00%

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Allele Name: prostaglandin E receptor 3 (subtype EP3); targeted mutation 1.1, Richard M Breyer
Symbol: Ptger3tm1.1Brey
MGI: MGI:5784744
Zygosity at cryopreservation Homozygous
PCR Genotyping Protocol Breyer_Lab_floxEP3_PCR_protocol.pdf
EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. (2007) Nat Neurosci 10: 1131-3 (Added 6/18/2019)
PMID: 17676060

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background 129S6/SvEvTac
Cryopreservation Strain Background (VCMR) BALB/c
Viability and Fertility Data

Viable and fertile.


Document Breyer_Lab_floxEP3_PCR_protocol.pdf - Added on June 18, 2019 at 1:42 PM by Jennifer Skelton

Document floxEP3BAL_info.docx - Added on June 18, 2019 at 1:42 PM by Jennifer Skelton