|Start Date / Time||June 26, 2019 at 9:00 AM|
|End Date / Time||June 26, 2019 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Emily M. Walker (Stein lab)|
|Presentation Title||Insight into the roles of the MAFA and MAFB transcription factors in human β cells|
|Status||This meeting has already occurred|
Using model systems, we have found that MAFA and MAFB are required for human β cell development, maintenance of mature cell identity, and function, and/or contribute to type 2 diabetes. Initially, I will present data concluding that the S64F mutation in MAFA which causes diabetes in primarily male patients, is due to induction of premature aging and senescence in β cells. In addition, I will discuss how in collaboration with Matthias Hebrok’s group at UCSF, we have found that MAFB is required for development and maintenance of β cells from pancreatic progenitor cells.