Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: BIG beta cell

Record History
Added on November 12, 2018 at 12:53 PM by Brown, Deborah
Modified on March 13, 2019 at 1:50 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Talk Master

Meeting Details

Start Date / Time April 17, 2019 at 9:00 AM
End Date / Time April 17, 2019 at 9:55 AM
Duration 55 minutes
Location 512 Light Hall
Presenter Name H. Efsun Arda, PhD (NIH/NCI)
Presentation Title Elucidating genomic enhancer function in human pancreas cells
Status This meeting has already occurred

Meeting Agenda/Notes

Determining the genetic and epigenetic factors involved in differentiation and maintenance of pancreatic cell lineages will be instrumental for developing targeted therapies. In our prior work, we combined cell purification methods with genomic assays to identify cell-type specific accessible genomic regions in primary human pancreas cells, and found putative enhancer elements corresponding to specific pancreas cell lineages. However, the mechanisms linking these regions to cell type-specific gene expression remained unclear. In my talk, I will present our new work on Hi-C linked with chromatin immunoprecipitation (HiChIP) assays using purified human pancreas cells to elucidate chromatin loops involving enhancer elements, as well as our efforts to perturb enhancer function in beta cells.