The investigators in this group seek to advance our understanding of the disordered clinical physiology and pathophysiology occurring in diabetes and diabetes related complications. The investigators are engaged in collaborative studies supported by the Vanderbilt Institute for Clinical and Translational Research (VICTR) Clinical Research Center. Areas of investigation include: in-vivo mechanisms responsible for the disordered endothelial function and increased thrombogenesis found in type 1 and type 2 diabetes; autonomic nervous system control of cardiovascular and metabolic regulation in healthy, obese and diabetic individuals; protein and energy balance in the setting of obesity and type 2 diabetes; effects of surgical interventions to reduce morbid obesity on endothelial dysfunction, insulin resistance, and type 2 DM; and in-vivo mechanisms responsible for tissue complications occurring in patients with type 2 DM.
These investigators at VUMC and Meharry Medical College are focused on a range of epidemiology research activities. The work is designed to achieve a common goal, namely to translate diabetes research advances into clinical or community practice. Important components of our work are understanding and reducing racial and ethnic health disparities. The P&C Core and its two units provide services to investigators with externally funded, diabetes-related translational research addressing the following areas: innovations in care, community engagement, culturally-sensitive/competent interventions, clinical trials, quality improvement, quality assurance, health services research, clinical and psychosocial epidemiology, public policy and environmental studies, and community-based participatory research.
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