Part of Vanderbilt DRTC's Weekly Seminar Series

Record History
Added on August 27, 2018 at 8:11 AM by Kimber, Jessica
Modified on August 30, 2018 at 7:49 AM by Kimber, Jessica
Shared with (contributions)
DRTC: DRTC Friday Seminar Series Master

Meeting Details

Start Date / Time September 28, 2018 at 12:00 PM
End Date / Time September 28, 2018 at 1:00 PM
Duration 1 hour(s)
Location 206 Preston Research Building
Presenter Name Craig Beall, PhD
Presentation Title The role of AMP-activated protein kinase in cellular low glucose sensing and whole body hypoglycaemia counterregulation
Status This meeting has already occurred

Meeting Agenda/Notes

Craig Beall, PhD
Research Fellow, Diabetes and Endocrinology
Exeter University

Hypoglycaemia in diabetes is still a frequent concern for people with diabetes and carries with it the increased risk of heart attacks, strokes and brain damage. The energy sensing enzyme, AMP-activated protein kinase (AMPK), is activated by glucose deprivation and has emerged as a critical regulator of whole body metabolism over the past 15 years, partly via central mechanisms. This talk will present findings that AMPK plays an important role in glucose-sensing cells including pancreatic beta cells and hypothalamic glucose excited neurons. We will also present data demonstrating that a novel brain permeable AMPK activator amplifies the counterregulatory response to hypoglycaemia in rats.