Part of Vanderbilt DRTC's Weekly Seminar Series

Record History
Added on August 27, 2018 at 7:59 AM by Kimber, Jessica
Modified on August 27, 2018 at 7:59 AM by Kimber, Jessica
Shared with (contributions)
DRTC: DRTC Friday Seminar Series Master

Meeting Details

Start Date / Time September 14, 2018 at 12:00 PM
End Date / Time September 14, 2018 at 1:00 PM
Duration 1 hour(s)
Location 206 Preston Research Building
Presenter Name Raymond C. Harris, MD
Presentation Title The EGF Receptor Family, Obesity and Diabetes
Status This meeting has already occurred

Meeting Agenda/Notes

Raymond C. Harris, MD
Director of Research, Division of Nephrology and Hypertension
Professor, Department of Molecular Physiology and Biophysics
Ann and Roscoe R. Robinson Chair in Nephrology
Vanderbilt University Medical Center

In recent studies, we have found that genetic or pharmacologic inhibition of the EGF receptor not only ameliorated the development of diabetic nephropathy in mouse models of type II diabetes but also preserved pancreatic islet function and insulin sensitivity. In contrast, mice with deletion of another member of this receptor family, ErbB4, led to development of obesity, dyslipidemia, hepatic steatosis and glucose intolerance, and NRG4, an ErbB4 ligand, inhibited lipogenesis and promoted adipocyte browning.