Current and ongoing beta cell research is presented in this weekly seminar by faculty, postdoctoral fellows and students. If you are interested in attending the Beta Cell Interest Group (BIG) seminars and joining the BIG community, please contact David Jacobson.

Keywords: BIG beta cell

Record History
Added on April 26, 2018 at 9:36 AM by Brown, Deborah
Modified on November 12, 2018 at 12:37 PM by Brown, Deborah
Shared with (contributions)
BIG: Beta Cell Interest Group (BIG) Master

Meeting Details

Start Date / Time November 14, 2018 at 9:00 AM
End Date / Time November 14, 2018 at 9:55 AM
Duration 55 minutes
Location 206 PRB
Presenter Name P. Mason McClatchey, PhD (Wasserman lab)
Presentation Title Engineering a Lymph-Isolated, Immediately-Perfused Graft for Islet Transplantation
Status This meeting has already occurred

Meeting Agenda/Notes

Traditional approaches to islet transplantation have suffered from either a complete lack of vascularization (i.e. encapsulation) or delayed and often insufficient vascularization (e.g. Edmonton protocol), both of which result in a loss of functional islet mass. This project aims to create a tissue-engineered construct that enables immediate perfusion by vascular anastomosis coupled with immune protection by isolation from lymphatic surveillance. Pilot studies support the plausibility of this project, but substantial challenges remain.