|Start Date / Time||November 14, 2018 at 9:00 AM|
|End Date / Time||November 14, 2018 at 9:55 AM|
|Presenter Name||P. Mason McClatchey, PhD (Wasserman lab)|
|Presentation Title||Engineering a Lymph-Isolated, Immediately-Perfused Graft for Islet Transplantation|
|Status||This meeting has already occurred|
Traditional approaches to islet transplantation have suffered from either a complete lack of vascularization (i.e. encapsulation) or delayed and often insufficient vascularization (e.g. Edmonton protocol), both of which result in a loss of functional islet mass. This project aims to create a tissue-engineered construct that enables immediate perfusion by vascular anastomosis coupled with immune protection by isolation from lymphatic surveillance. Pilot studies support the plausibility of this project, but substantial challenges remain.