In these mice the first exon of Efna1 gene, which encodes EphrinA1, was replaced with a neomycin resistance cassette.  The absence of protein expression was confirmed by Western blot analysis of P0 lung extracts.

Keywords: Efna1 Ephrin-A1

Record History
Added on April 17, 2018 at 11:18 AM by Skelton, Jennifer
Modified on December 6, 2018 at 9:37 AM by Skelton, Jennifer
Shared with (contributions)
VCMR: Vanderbilt Cryopreserved Mouse Repository Master

Mouse Information

Common Name Efna1 KO/BalbC
Research Applications Not provided
MMRRC ID Not provided
Jackson Laboratories Stock No Not provided
VCMR ID OJ
Additional Strain Information Not provided

Genetic Alteration

Mutation #1: Targeted Mutagenesis
Type of AlleleConditional Null
Targeted GeneName: ephrin A1
Symbol:Efna1
Allele Name: ephrin A1; targeted mutation 1, Jin Chen
Symbol: Efna1tm1Jinc
MGI: MGI:4849544
Description of Targeting Vector Not provided
Vector Genbank File Not provided
Allele Map Not Provided
PCR Genotyping Protocol Efna1_KO_PCR_Protocol.docx
Citations
Publication
Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1. (2010) Dev Dyn 239: 3226-34 (Added 11/13/2013)
PMID: 20960543

Background Strain Information

Strain Type Congenic Strain
Chimera/Founder Genetic Background 129X1/SvJ
Current Genetic Background BALB/c
Number of Generations Backcrossed >10
Strain Description Not provided