|Start Date / Time||April 18, 2018 at 9:00 AM|
|End Date / Time||April 18, 2018 at 10:00 AM|
|Presenter Name||Ethan Lippmann, Ph.D.|
|Presentation Title||Neurovascular modeling and biological discovery with human iPSCs|
|Status||This meeting has already occurred|
Human blood-brain barrier (BBB) models are highly desirable for applications in drug discovery and disease modeling but have historically been limited by a lack of quality sources of brain endothelial cells. In this talk, I will detail my group's ongoing efforts to create a human BBB model from induced pluripotent stem cells (iPSCs) that faithfully represents the qualities of the BBB in vivo. I will also provide examples for how we are using our differentiation schemes to determine the molecular underpinnings of BBB function and how we are incorporating iPSC-derived brain endothelial cells into engineered tissue constructs to create more complex human neurovascular models.