Start Date / Time | April 18, 2018 at 9:00 AM |
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End Date / Time | April 18, 2018 at 10:00 AM |
Duration | 1 hour(s) |
Location | 9455MRB IV |
Presenter Name | Ethan Lippmann, Ph.D. |
Presentation Title | Neurovascular modeling and biological discovery with human iPSCs |
Status | This meeting has already occurred |
Human blood-brain barrier (BBB) models are highly desirable for applications in drug discovery and disease modeling but have historically been limited by a lack of quality sources of brain endothelial cells. In this talk, I will detail my group's ongoing efforts to create a human BBB model from induced pluripotent stem cells (iPSCs) that faithfully represents the qualities of the BBB in vivo. I will also provide examples for how we are using our differentiation schemes to determine the molecular underpinnings of BBB function and how we are incorporating iPSC-derived brain endothelial cells into engineered tissue constructs to create more complex human neurovascular models.
Spring_2018_Email_Notice_Lippmann.pdf - Added on April 12, 2018 at 2:10 PM by Pam Uttz