NOTICE: Labnodes now supports email addresses. If your email changed, please update your profile today.


  Anna Osipovich, Ph.D.
  Research Assistant Professor, Mark Magnuson Lab
  JP Cartailler, Ph.D., Director, Creative Data Solutions


Record History
Added on January 4, 2018 at 1:19 PM by Uttz, Pam
Modified on March 16, 2018 at 10:28 AM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time March 21, 2018 at 9:00 AM
End Date / Time March 21, 2018 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name JP Cartailler, Ph.D. and Anna Osipovich, Ph.D.
Presentation Title iterativeWGCNA: An improvement to gene co-expression network inference and its use in exploring pancreatic beta cell development
Status This meeting has already occurred

Meeting Agenda/Notes

We will describe an extension for Weighted-gene correlation network analysis (WGCNA) that improves the identification of modules of co-expressed genes within whole-transcriptome datasets. This extension, called iterativeWGCNA, provides an unsupervised, non-biased filtering method that improves the robustness of detected modules and minimizes information loss. We have used iterativeWGCNA to calculate a gene co-expression network that traces the developmental lineage of mouse β-cells.  Analysis of the network enabled us to identify the stage-specific expression of clustered protocadherin genes and to identify 81 C2H2 zinc finger proteins whose expression is correlated with endocrine specification and β-cell maturation.


Document Spring_2018_Email_Notice_Cartailler_Osipovich.pdf - Added on March 16, 2018 at 10:27 AM by Pam Uttz