Anna Osipovich, Ph.D.
  Research Assistant Professor, Mark Magnuson Lab
  JP Cartailler, Ph.D., Director, Creative Data Solutions

 


Record History
Added on January 4, 2018 at 1:19 PM by Uttz, Pam
Modified on March 16, 2018 at 10:28 AM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time March 21, 2018 at 9:00 AM
End Date / Time March 21, 2018 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name JP Cartailler, Ph.D. and Anna Osipovich, Ph.D.
Presentation Title iterativeWGCNA: An improvement to gene co-expression network inference and its use in exploring pancreatic beta cell development
Status This meeting has already occurred

Meeting Agenda/Notes

We will describe an extension for Weighted-gene correlation network analysis (WGCNA) that improves the identification of modules of co-expressed genes within whole-transcriptome datasets. This extension, called iterativeWGCNA, provides an unsupervised, non-biased filtering method that improves the robustness of detected modules and minimizes information loss. We have used iterativeWGCNA to calculate a gene co-expression network that traces the developmental lineage of mouse β-cells.  Analysis of the network enabled us to identify the stage-specific expression of clustered protocadherin genes and to identify 81 C2H2 zinc finger proteins whose expression is correlated with endocrine specification and β-cell maturation.

Attachment

Document Spring_2018_Email_Notice_Cartailler_Osipovich.pdf - Added on March 16, 2018 at 10:27 AM by Pam Uttz