Young Wook Chun, Ph.D.
  Research Assistant Professor, Charles Hong Lab

Record History
Added on January 4, 2018 at 1:14 PM by Uttz, Pam
Modified on February 16, 2018 at 1:15 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time February 21, 2018 at 9:00 AM
End Date / Time February 21, 2018 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name Young Wook Chun, Ph.D.
Presentation Title Rotatin is a new causal gene for congenital dilated cardiomyopathy
Status This meeting has already occurred

Meeting Agenda/Notes

We have generated iPSC-CMs for a child with congenital dilated cardiomyopathy and found significant impairment in contractility and mitochondrial function, and recapitulated structural defects found in patient’s iPSC-CMs. CRISPR-Cas9-mediated knockout of RTTN, putative causal gene identified by next gen sequencing technology, recapitulated cardiomyocyte defects, and the correction of the missense mutation in the disease iPSCs restored cardiomyocyte structure and function, confirming causality. It suggests that RTTN may be important gene in cardiac regulation.



Document Spring_2018_Email_Notice_Chun.pdf - Added on February 16, 2018 at 1:15 PM by Pam Uttz