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Lauren Woodard, Ph.D.
Division of Nephrology & Hypertension
|Start Date / Time||January 24, 2018 at 9:00 AM|
|End Date / Time||January 24, 2018 at 10:00 AM|
|Location||9455 MRB IV|
|Presenter Name||Lauren Woodard, Ph.D.|
|Presentation Title||Regenerating the kidney via transposon-based reprogramming to induced nephron progenitors|
|Status||This meeting has already occurred|
Less than half of patients with acute kidney injury survive 90 days. In part this is because the adult mammalian kidney cannot make new nephrons, however, embryonic nephron progenitors are capable of forming all parts of the nephron. Direct reprogramming to an induced nephron progenitor state from human tubule cells will be described, including our inducible piggyBac transposon reprogramming strategy and dereplication of the transcription factors required (SIX1, EYA1, and SNAI2).
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Released July 13, 2020