|Start Date / Time||February 28, 2018 at 9:00 AM|
|End Date / Time||February 28, 2018 at 9:55 AM|
|Location||512 Light Hall|
|Presenter Name||Xiaodun Yang (Gu's laboratory)|
|Presentation Title||Sin3A is required to maintain pancreatic β-cell function and survival after birth|
|Status||This meeting has already occurred|
My talk mainly focuses on the roles of a transcription cofactor Sin3A (SWI-independent-3A) in β-cell function and survival. Sin3A can interact with transcription factors (TFs) to recruit chromatin-modifying enzymes to regulate the expression of target genes. Furthermore, Sin3A has been shown to interact with two TFs required for β-cell function and survival, MafA and Myt1, suggesting its potential roles in β cells. In my talk, I will first show the expression of Sin3A in pancreas at embryonic stages and after birth. Next, I will show the data of loss of Sin3A in pancreatic endocrine progenitors and in pancreatic progenitors. My data suggest that Sin3A is essential to maintain β-cell function and survival after birth.