M. Diana Neely, Ph.D.
Research Associate Professor of Pediatrics

Record History
Added on September 8, 2017 at 2:28 PM by Uttz, Pam
Modified on November 21, 2017 at 2:52 PM by Uttz, Pam
Shared with (contributions)
Public: SPRING Meeting

Meeting Details

Start Date / Time November 29, 2017 at 9:00 AM
End Date / Time November 29, 2017 at 10:00 AM
Duration 1 hour(s)
Location 9455 MRB IV
Presenter Name M. Diana Neely, Ph.D.
Presentation Title Environmental toxicants and the development of iPSC-derived human neurons
Status This meeting has already occurred

Meeting Agenda/Notes

The adverse effects of environmental chemicals on the development of the nervous system is recognized worldwide as an important problem. Most assessments of the effects of such toxicants are performed in the rodents but little is known how these compounds affect the development of the human nervous system in particular. We have developed methods to differentiate cortical glutamatergic and mesencephalic dopaminergic neurons from human-induced pluripotent stem cells and are assessing the effects and the mechanisms of actions of known neurotoxicants on the development of these human neurons. We find that metals such as manganese and the pesticides rotenone and ziram affect a wide variety of cellular functions including mitochondria, neurotransmitter release and ubiquitin signaling in these developing human neurons.



Document Spring_2017_Email_Notice_Neely.pdf - Added on November 21, 2017 at 2:52 PM by Pam Uttz