|Start Date / Time||November 29, 2017 at 9:00 AM|
|End Date / Time||November 29, 2017 at 10:00 AM|
|Location||9455 MRB IV|
|Presenter Name||M. Diana Neely, Ph.D.|
|Presentation Title||Environmental toxicants and the development of iPSC-derived human neurons|
|Status||This meeting is currently scheduled|
The adverse effects of environmental chemicals on the development of the nervous system is recognized worldwide as an important problem. Most assessments of the effects of such toxicants are performed in the rodents but little is known how these compounds affect the development of the human nervous system in particular. We have developed methods to differentiate cortical glutamatergic and mesencephalic dopaminergic neurons from human-induced pluripotent stem cells and are assessing the effects and the mechanisms of actions of known neurotoxicants on the development of these human neurons. We find that metals such as manganese and the pesticides rotenone and ziram affect a wide variety of cellular functions including mitochondria, neurotransmitter release and ubiquitin signaling in these developing human neurons.